Lum and Abner was an American network radio comedy program created by Chester Lauck and Norris Goff that was produced from 1931 to 1954. Modeled on life in the small town of Waters, Arkansas, near where Lauck and Goff grew up, the show proved immensely popular. In 1936, Waters changed its name to "Pine Ridge" after the show's fictional town.

Amos 'n' Andy is an American radio sitcom about black characters, initially set in Chicago then later in the Harlem section of New York City. While the show had a brief life on 1950s television with black actors, the 1928 to 1960 radio show was created, written and voiced by two white actors, Freeman Gosden and Charles Correll.

Fibber McGee and Molly (1935–1959) was a longtime American husband-and-wife team radio comedy program. The situation comedy was a staple of the NBC Red Network from 1936 on, after originating on NBC Blue in 1935. One of the most popular and enduring radio series of its time, it ran as a stand-alone series from 1935 to 1956, and then continued as a short-form series as part of the weekend Monitor from 1957 to 1959.

The Alan Young Show was a 30 minute situation comedy that ran from 1944 thru 1949. In 1944, Canadian actor Alan Young was hired away from the Canadian Broadcasting Company (CBC) radio, by NBC Radio, as a summer replacement for "The Eddie Cantor Show.

The George Burns and Gracie Allen Show, sometimes called The Burns and Allen Show, is a half-hour television sitcom broadcast from 1950 to 1958 on CBS. It starred George Burns and Gracie Allen, one of the most enduring acts in entertainment history. Burns and Allen were headliners in vaudeville in the 1920s, and radio stars in the 1930s and 1940s.

The Aldrich Family, a popular radio teenage situation comedy (July 2, 1939 – April 19, 1953), was also presented in films, television and comic books. In the radio series' opening exchange, awkward teen Henry's mother called, "Hen-ry-y-y-y! Hen-ry Al-drich!", and he responded with a breaking adolescent voice, "Com-ing, Mother!"

The Adventures of Maisie (aka Maisie)" was a radio comedy series starring Ann Sothern, as under-employed entertainer Maisie Ravier and a spin-off of Sothern's successful 1939-1947 Maisie movie series. It is this OTR program which popularized the 1940s catch phrase Liiiikewiiise, I'm suuuuurrrre.

The Pepsodent Show is an American radio comedy program broadcast from 1938 to 1948, during the Golden Age of Radio. The program starred Bob Hope and Jerry Colonna, alongside Blanche Stewart, Elvia Allman, and a continuously rotating supporting cast of actors and musicians which included, for a time, Judy Garland, Frances Langford, and Desi Arnaz and his orchestra.

Granby's Green Acres is a radio situation comedy from the United States. It was broadcast on CBS July 3, 1950 – August 21, 1950, as a summer replacement for Lux Radio Theatre. Granby's Green Acres featured a former banker who knew little about farming and proved it every week.